CVE-2021-43355 | Fresenius Kabi Agilia Connect Infusion System use of client side authentication

Fresenius Kabi Vigilant Software Suite (Mastermed Dashboard) version 2.0.1.3 allows user input to be validated on the client side without authentication by the server. The server should not rely on the correctness of the data because users might not support or block JavaScript or intentionally bypass the client-side checks. An attacker with knowledge of the service user could circumvent the client-side control and login with service privileges.

Published: 2022-01-21 Last update: 2024-11-21 Assigner: [email protected] Source: [email protected]
NVD Status：Modified，CVE State: published
View at NVD, CVE.org, EUVD

CVE-2021-43355 is rated Moderate Risk (45.1/100): CVSS High severity, with low exploitation likelihood (EPSS 0.22%). Review affected assets and schedule remediation.

Risk is dynamic; we continuously reassess and refresh what is shown on this page as upstream context changes.

Exploit prediction scoring system (EPSS) score for CVE-2021-43355

EPSS lead: Daily EPSS estimates relative likelihood of exploitation; percentile ranks this CVE among scored vulnerabilities (higher = more severe relative rank).

# Date Old EPSS score New EPSS score Delta (New - Old)
1 2025-08-10 0.07% 0.22% +0.15%
2 2025-03-17 0.29% 0.07% -0.22%
3 2024-10-20 — 0.29% —

Full EPSS history (6 records total)

Common vulnerability scoring system (CVSS) metrics for CVE-2021-43355

CVSS metrics for this CVE.

Base score Version Severity Vector Exploitability Impact Score source
7.3 3.1 HIGH
CVSS:3.1/AV:N/AC:L/PR:N/UI:N/S:U/C:L/I:L/A:L Click to expand
Attack vector (AV:N)
Could be attacked over the internet or any normal routed network—not just someone sitting at the machine.
Attack complexity (AC:L)
Once they can reach the bug, pulling it off is straightforward—no weird race conditions or rare setup.
Privileges required (PR:N)
No account or special rights needed—anonymous or random user is enough.
User interaction (UI:N)
Nobody has to click “OK” or open a trap file; it can work without a victim helping.
Scope (S:U)
Damage stays in the same “trust bubble” as the broken component—no big spill into unrelated systems.
Confidentiality (C:L)
Some sensitive info could get out, but not a total data dump.
Integrity (I:L)
Attackers could change some data, but it’s limited—not everything goes.
Availability (A:L)
Might cause slowdowns, glitches, or partial disruption—not a full brick.
 3.9 3.4 [email protected]
9.8 3.1 CRITICAL
CVSS:3.1/AV:N/AC:L/PR:N/UI:N/S:U/C:H/I:H/A:H Click to expand
Attack vector (AV:N)
Could be attacked over the internet or any normal routed network—not just someone sitting at the machine.
Attack complexity (AC:L)
Once they can reach the bug, pulling it off is straightforward—no weird race conditions or rare setup.
Privileges required (PR:N)
No account or special rights needed—anonymous or random user is enough.
User interaction (UI:N)
Nobody has to click “OK” or open a trap file; it can work without a victim helping.
Scope (S:U)
Damage stays in the same “trust bubble” as the broken component—no big spill into unrelated systems.
Confidentiality (C:H)
Serious risk that confidential data gets exposed in a big way.
Integrity (I:H)
They could widely tamper with or forge data—trust in the data is badly hurt.
Availability (A:H)
Could take the service down hard or make it unusable for people who depend on it.
 3.9 5.9 [email protected]
7.5 2.0 HIGH
AV:N/AC:L/Au:N/C:P/I:P/A:P Click to expand
Access vector (AV:N)
Can be exploited remotely over network reachability.
Access complexity (AC:L)
Exploitation conditions are straightforward and predictable.
Authentication (AU:N)
No authentication is required.
Confidentiality impact (C:P)
Partial confidentiality impact.
Integrity impact (I:P)
Partial integrity impact.
Availability impact (A:P)
Partial availability impact.
 10.0 6.4 [email protected]

Weakness enumeration for CVE-2021-43355

Affected software / configurations for CVE-2021-43355

Vendor Product Version Raw CPE
fresenius-kabi agilia_partner_maintenance_software <= 3.3.0 cpe:2.3:a:fresenius-kabi:agilia_partner_maintenance_software:*:*:*:*:*:*:*:*
fresenius-kabi vigilant_centerium 1.0 cpe:2.3:a:fresenius-kabi:vigilant_centerium:1.0:*:*:*:*:*:*:*
fresenius-kabi vigilant_insight 1.0 cpe:2.3:a:fresenius-kabi:vigilant_insight:1.0:*:*:*:*:*:*:*
fresenius-kabi vigilant_mastermed 1.0 cpe:2.3:a:fresenius-kabi:vigilant_mastermed:1.0:*:*:*:*:*:*:*
fresenius-kabi agilia_connect_firmware <= d25 cpe:2.3:o:fresenius-kabi:agilia_connect_firmware:*:*:*:*:*:*:*:*
fresenius-kabi link\+_agilia_firmware < 3.0 cpe:2.3:o:fresenius-kabi:link\+_agilia_firmware:*:*:*:*:*:*:*:*
fresenius-kabi link\+_agilia_firmware 3.0 cpe:2.3:o:fresenius-kabi:link\+_agilia_firmware:3.0:-:*:*:*:*:*:*
fresenius-kabi link\+_agilia_firmware 3.0 cpe:2.3:o:fresenius-kabi:link\+_agilia_firmware:3.0:d15:*:*:*:*:*:*

References for CVE-2021-43355

URL Tags
https://www.cisa.gov/uscert/ics/advisories/icsma-21-355-01 Third Party Advisory US Government Resource
cvelogic Threat Intelligence