A use of uninitialized pointer vulnerability exists in the PQS format pFormat functionality of Open Babel 3.1.1 and master commit 530dbfa3. A specially crafted malformed file can lead to arbitrary code execution. An attacker can provide a malicious file to trigger this vulnerability.
Conclusion & alert: CVE-2022-46280 is rated High Exploit Risk (75.9/100): CVSS Critical severity, with medium exploitation likelihood (EPSS 0.42%). Core evidence: 1 public exploit reference(s) are indexed (Exploit-DB). Mandatory action: Public exploits are available—assess exposure, apply mitigations, and prioritize patching.
Risk is dynamic; we continuously reassess and refresh what is shown on this page as upstream context changes.
| EDB-ID | Source | Kind | Published | Link |
|---|---|---|---|---|
| — | nvd_ref | exploit_tag | Exploit-DB ↗ |
EPSS lead: Daily EPSS estimates relative likelihood of exploitation; percentile ranks this CVE among scored vulnerabilities (higher = more severe relative rank).
| # | Date | Old EPSS score | New EPSS score | Delta (New - Old) |
|---|---|---|---|---|
| 1 | 2026-04-15 | 0.34% | 0.42% | +0.07% |
| 2 | 2025-11-21 | 0.52% | 0.34% | -0.17% |
| 3 | 2025-11-18 | — | 0.52% | — |
Full EPSS history (8 records total)
CVSS metrics for this CVE.
| Base score | Version | Severity | Vector | Exploitability | Impact | Score source |
|---|---|---|---|---|---|---|
| 9.8 | 3.1 | CRITICAL |
|
3.9 | 5.9 | [email protected] |
| 7.8 | 3.1 | HIGH |
|
1.8 | 5.9 | [email protected] |
| vendor | priority | summary | link |
|---|---|---|---|
debian
|
not yet assigned | CVE-2022-46280 not yet assigned priority: Debian including 1 source packages (openbabel), 5 status rows across 5 suites (bookworm, bullseye, forky, sid, trixie): open 5. | https://security-tracker.debian.org/tracker/CVE-2022-46280 |
ubuntu
|
medium | CVE-2022-46280 medium priority: Ubuntu including 1 source packages (openbabel), 12 status rows across 12 suites (bionic, focal, jammy, lunar, mantic, noble, oracular, plucky, questing, trusty, upstream, xenial): ignored 5, needs-triage 4, needed 3. | https://ubuntu.com/security/CVE-2022-46280 |
| Vendor | Product | Version | Raw CPE |
|---|---|---|---|
| openbabel | open_babel | 3.1.1 | cpe:2.3:a:openbabel:open_babel:3.1.1:*:*:*:*:*:*:* |
| URL | Tags |
|---|---|
| https://talosintelligence.com/vulnerability_reports/TALOS-2022-1670 | Exploit Third Party Advisory Vendor Advisory |
| https://www.talosintelligence.com/vulnerability_reports/TALOS-2022-1670 |