CVE-2024-50636

PyMOL 2.5.0 contains a vulnerability in its "Run Script" function, which allows the execution of arbitrary Python code embedded within .PYM files. Attackers can craft a malicious .PYM file containing a Python reverse shell payload and exploit the function to achieve Remote Command Execution (RCE). This vulnerability arises because PyMOL treats .PYM files as Python scripts without properly validating or restricting the commands within the script, enabling attackers to run unauthorized commands in the context of the user running the application.

Published: 2024-11-11 Last update: 2026-06-17 Assigner: [email protected] Source: [email protected]
NVD Status：Deferred，CVE State: published
View at NVD, CVE.org, EUVD

CVE-2024-50636 is rated Moderate Risk (56.7/100): CVSS Critical severity, with medium exploitation likelihood (EPSS 1.21%). Review affected assets and schedule remediation.

Risk is dynamic; we continuously reassess and refresh what is shown on this page as upstream context changes.

Exploit prediction scoring system (EPSS) score for CVE-2024-50636

EPSS lead: Daily EPSS estimates relative likelihood of exploitation; percentile ranks this CVE among scored vulnerabilities (higher = more severe relative rank).

# Date Old EPSS score New EPSS score Delta (New - Old)
1 2026-06-15 6.96% 1.21% -5.75%
2 2026-04-02 5.25% 6.96% +1.71%
3 2026-01-26 — 5.25% —

Full EPSS history (17 records total)

Common vulnerability scoring system (CVSS) metrics for CVE-2024-50636

CVSS metrics for this CVE.

Base score Version Severity Vector Exploitability Impact Score source
9.8 3.1 CRITICAL
CVSS:3.1/AV:N/AC:L/PR:N/UI:N/S:U/C:H/I:H/A:H Click to expand
Attack vector (AV:N)
Could be attacked over the internet or any normal routed network—not just someone sitting at the machine.
Attack complexity (AC:L)
Once they can reach the bug, pulling it off is straightforward—no weird race conditions or rare setup.
Privileges required (PR:N)
No account or special rights needed—anonymous or random user is enough.
User interaction (UI:N)
Nobody has to click “OK” or open a trap file; it can work without a victim helping.
Scope (S:U)
Damage stays in the same “trust bubble” as the broken component—no big spill into unrelated systems.
Confidentiality (C:H)
Serious risk that confidential data gets exposed in a big way.
Integrity (I:H)
They could widely tamper with or forge data—trust in the data is badly hurt.
Availability (A:H)
Could take the service down hard or make it unusable for people who depend on it.
 3.9 5.9 134c704f-9b21-4f2e-91b3-4a467353bcc0

Weakness enumeration for CVE-2024-50636

OS Trackers for CVE-2024-50636

vendor priority summary link
ubuntu medium CVE-2024-50636 medium priority: Ubuntu including 1 source packages (pymol), 9 status rows across 9 suites (bionic, focal, jammy, noble, oracular, plucky, questing, upstream, xenial): needs-triage 7, ignored 2. https://ubuntu.com/security/CVE-2024-50636

Affected software / configurations for CVE-2024-50636

Vendor Product Version Raw CPE
No affected products in dataset.

References for CVE-2024-50636

cvelogic Threat Intelligence