CVE-2025-68463

Bio.Entrez in Biopython through 186 allows doctype XXE.

Published: 2025-12-18 Last update: 2026-05-08 Assigner: [email protected] Source: [email protected]
NVD Status：Deferred，CVE State: published
View at NVD, CVE.org, EUVD

CVE-2025-68463 is rated Low Risk (23.7/100): CVSS Medium severity, with low exploitation likelihood (EPSS 0.04%). Monitor for updates and reassess as exploit intelligence or EPSS changes.

Risk is dynamic; we continuously reassess and refresh what is shown on this page as upstream context changes.

Exploit prediction scoring system (EPSS) score for CVE-2025-68463

EPSS lead: Daily EPSS estimates relative likelihood of exploitation; percentile ranks this CVE among scored vulnerabilities (higher = more severe relative rank).

# Date Old EPSS score New EPSS score Delta (New - Old)
1 2026-05-16 0.05% 0.04% -0.01%
2 2026-02-24 0.03% 0.05% +0.02%
3 2025-12-18 — 0.03% —

Full EPSS history (3 records total)

Common vulnerability scoring system (CVSS) metrics for CVE-2025-68463

CVSS metrics for this CVE.

Base score Version Severity Vector Exploitability Impact Score source
4.9 3.1 MEDIUM
CVSS:3.1/AV:N/AC:H/PR:L/UI:N/S:C/C:L/I:N/A:L Click to expand
Attack vector (AV:N)
Could be attacked over the internet or any normal routed network—not just someone sitting at the machine.
Attack complexity (AC:H)
Even with access, the exploit needs extra luck, timing, or a fussy environment to actually work.
Privileges required (PR:L)
A normal user session is enough; they don’t have to be admin.
User interaction (UI:N)
Nobody has to click “OK” or open a trap file; it can work without a victim helping.
Scope (S:C)
Breaking this can reach past the original component and bite other resources—bigger blast radius.
Confidentiality (C:L)
Some sensitive info could get out, but not a total data dump.
Integrity (I:N)
Data isn’t meaningfully altered or forged.
Availability (A:L)
Might cause slowdowns, glitches, or partial disruption—not a full brick.
 1.8 2.7 [email protected]

Weakness enumeration for CVE-2025-68463

GitHub Security Advisory for CVE-2025-68463

GHSA-x3vf-39hj-gxr4 · Severity: medium · Ecosystem: pip — Biopython is vulnerable to doctype XML external entity (XXE) injection through Bio.Entrez

OS Trackers for CVE-2025-68463

vendor priority summary link
debian not yet assigned CVE-2025-68463 not yet assigned priority: Debian including 1 source packages (python-biopython), 5 status rows across 5 suites (bookworm, bullseye, forky, sid, trixie): open 3, resolved 2. https://security-tracker.debian.org/tracker/CVE-2025-68463
redhat medium — https://access.redhat.com/security/cve/CVE-2025-68463
ubuntu medium CVE-2025-68463 medium priority: Ubuntu including 1 source packages (python-biopython), 8 status rows across 8 suites (bionic, focal, jammy, noble, plucky, questing, upstream, xenial): needs-triage 7, ignored 1. https://ubuntu.com/security/CVE-2025-68463

Affected software / configurations for CVE-2025-68463

Vendor Product Version Raw CPE
No affected products in dataset.

References for CVE-2025-68463

cvelogic Threat Intelligence